Huang-Yi Li

• 日期 : 2024-07-14
• 分類 :
• 點閱 : 1447

學歷:

國立陽明交通大學生化暨分子生物研究所 博士 2022 

淡江大學生命科學研究所 碩士 2010

淡江大學化學系 學士 2008

 

經歷:

東海大學化學系助理教授 2025-present

中央研究院基因體研究中心 博士後研究學者 2022-2025

 

專長:

有機合成, 生物有機化學, 化學生物學, 生物活性分子設計與效果鑑定

 

期刊:

• Huang-Yi Li*, Ser John Lynon P. Perez, Hui-Lan Chang, Hsuan-Hsuan Lo, Chia-Ning Yang*, Wei-Chieh Cheng*. Design and synthesis of polyhydroxylated azabicyclo[3.3.1]nonane as selective lysosomal α-glucosidase stabilizers enhancing cellular uptake. Bioorg. Chem. 2025, 165, 108994. (SCIE, IF: 4.7, Q1, 5/57 (7.9%) in CHEMISTRY, ORGANIC, 2024)
• Huang-Yi Li, Wei-An Chen, Hung-Yi Lin, Chi-Wei Tsai, Yu-Ting Chiu, Wen-Yi Yun and Wei-Chieh Cheng. A Practical Synthesis of Nitrone-derived C5a-Functionalized Isofagomines as Protein Stabilizers to Treat Gaucher Disease. Commun. Chem. 2024, 7, 91 (IF: 6.2, Q1, 50/239 (20.7%) in CHEMISTRY, MULTIDISCIPLINARY, 2024)
• Huang-Yi Li, Hung-Yi Lin, Sheng-Kai Chang, Yu-Ting Chiu, Chung-Chien Hou, Tzu-Ping Ko, Kai-Fa Huang, Dau-Ming Niu and Wei-Chieh Cheng. Mechanistic insights into dibasic iminosugars as pH-selective pharmacological chaperones to stabilize human α-galactosidase. JACS Au 2024, 4, 908-918 (IF: 8.7, Q1, 38/239 (15.7%) in CHEMISTRY, MULTIDISCIPLINARY, 2024)
• Hung-Yi Lin, Shih-Ying Chang, Hsuan-Hsuan Teng, Hsi-Ju Wu, Huang-Yi Li, Chia-Chun Cheng, Chih-Kuang Chuang, Hsiang-Yu Lin, Shuan-Pei Lin and Wei-Chieh Cheng. Discovery of small-molecule protein stabilizers toward exogenous alpha-l-iduronidase to reduce the accumulated heparan sulfate in mucopolysaccharidosis type I cells. Eur. J. Med. Chem. 2023, 247, 115005. (IF: 5.9, Q1, 10/72 (13.2%) in CHEMISTRY, MEDICINAL, 2024)
• Huang-Yi Li, Ni-Chung Lee, Yu-Ting Chiu, Yu-Wen Chang, Chu-Chung Lin, Cheng-Li Chou, Yin-Hsiu Chien, Wuh-Liang Hwu and Wei-Chieh Cheng. Harnessing polyhydroxylated pyrrolidines as a stabilizer of acid alpha-glucosidase (GAA) to enhance the efficacy of enzyme replacement therapy in Pompe disease. Bioorg. Med. Chem. 2023, 78, 117129. (IF: 3.0, Q1, 12/57 (20.2%) in CHEMISTRY, ORGANIC, 2024)
• Wei-An Chen, Huang-Yi Li (co-first author), Ashik Sayyad, Chun-Yen Huang and Wei-Chieh Cheng. Synthesis of Nitrone-derived Pyrrolidine Scaffolds and Their Combinatorial Libraries to Develop Selective α-L-Rhamnosidase Inhibitors. Chem. Asian J. 2022, 17, e202200172. (IF: 3.3, Q2, 102/239 (42.5%) in CHEMISTRY, MULTIDISCIPLINARY, 2024)
• Wei-Chieh Cheng, Cheng-Kun Lin, Huang-Yi Li, Yu-Chien Chang, Sheng-Jhih Lu, Yu-Shin Chen and Shih-Ying Chang. A combinatorial approach towards the synthesis of non-hydrolysable triazole–iduronic acid hybrid inhibitors of human α-l-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPSI. Chem. Commun. 2018, 54, 2647-2650 (IF: 4.3, 71/230 in CHEMISTRY, MULTIDISCIPLINARY, 2023)
• Huang-Yi Li, Jay-Der Lee, Chiao-Wen Chen, Ying-Chieh Sun and Wei-Chieh Cheng. Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines. Eur. J. Med. Chem. 2018, 144, 626-634. (IF: 6.0, Q1, 8/72 (10.4%) in CHEMISTRY, MEDICINAL, 2023)
• Wei-Chieh Cheng, Jen-Hon Wang, Wen-Yi Yun, Huang-Yi Li and Jia-Ming Hu. Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease. Eur. J. Med. Chem. 2017, 126, 1-6. (IF: 6.0, Q1, 8/72 (10.4%) in CHEMISTRY, MEDICINAL, 2023)
• Wei-Chieh Cheng, Jen-Hon Wang, Huang-Yi Li, Sheng-Jhih Lu, Jia-Ming Hu, Wen-Yi Yun, Cheng-Hsin Chiu, Wen-Bin Yang, Yin-Hsiu Chien and Wuh-Liang Hwu. Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency. Eur. J. Med. Chem. 2016, 123, 14-20. (IF: 6.0, Q1, 8/72 (10.4%) in CHEMISTRY, MEDICINAL, 2023)
• Cheng-Kun Lin, Li-Wei Cheng, Huang-Yi Li, Wen-Yi Yun and Wei-Chieh Cheng. Synthesis of novel polyhydroxylated pyrrolidine–triazole/-isoxazole hybrid molecules. Org. Biomol. Chem. 2015, 13, 2100-2107. (IF: 2.9, Q1, 13/58 (21.6%) in CHEMISTRY, ORGANIC, 2023)
• Ming-Kai Chen, Huang-Yi Li, Po-Fan Chen, Su-Fang Chien. Taro α-galactosidase: A new gene product for blood conversion. Biocatal. Agric. Biotechnol. 2012, 1, 135-139. (IF: 3.4, Q2, 69/174 (39.4%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 2023)